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Enfortumab vedotin-ejfv (solution)

CAT: 0804-HY-P99016B-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99016B-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Enfortumab vedotin-ejfv (solution) is an anti-Nectin-4 antibody-drug conjugate (ADC). Enfortumab vedotin-ejfv (solution) is a fully humanized IgG1 antibody conjugated to the microtubule disrupting agent MMAE via a protease-cleavable Val-Cit linker. The antibody portion is Enfortumab (HY-P99016), and the drug-linker conjugate for ADC is VcMMAE (HY-15575). Nectin-4 is an adhesion protein involved in cellular processes and tumorigenesis, and Enfortumab vedotin-ejfv (solution) is indicated for the inhibition of locally advanced or metastatic urothelial carcinoma[1][2].
CAS Number
1346452-25-2
UNSPSC
12352203
Target
Antibody-Drug Conjugates (ADCs) ; Nectin-4
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/enfortumab-vedotin-ejfv-solution.html
Purity
99.78
Solubility
10 mM in DMSO
Smiles
[Enfortumabvedotin-ejfv(solution)]
Molecular Weight
152000 (average)
References & Citations
[1]Mantia CM, et al. Enfortumab vedotin-ejfv for the treatment of advanced urothelial carcinoma. Expert Rev Anticancer Ther. 2022;22 (5) :449-455.|[2]Halford Z, et al. Enfortumab Vedotin-ejfv: A First-in-Class Anti-Nectin-4 Antibody-Drug Conjugate for the Management of Urothelial Carcinoma. Ann Pharmacother. 2021;55 (6) :772-782.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, protect from light
Scientific Category
ADC Related
Clinical Information
No Development Reported

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