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Mouse IL-34 Recombinant Protein

CAT: 0519-R06903Size: 5 µgDry Ice: NoHazardous: No
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CAT#:0519-R06903Size:5 µg
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Description
Interleukin-34 (IL-34) is a homodimeric cytokine recognized by colony-stimulating factor 1 receptor (CSF-1R) . IL-34 is involved in the survival, proliferation, and differentiation of mononuclear phagocytes. Mouse IL-34 Recombinant Protein is purified interleukin-15 produced in yeast.
Synonyms
Interleukin-34; IL-34; Il34
Gene Name
IL34
UniProt
Q8R1R4
Source
Yeast
Sequence
[object Object]
Applications
Cell Culture
Field of Research
Cytokines, Immunology, Innate Immunity, Interleukins, Macrophage/Inflammation
Purification
Ion-exchange chromatography.
Bioactivity
In testing.
Form
Lyophilized
Function
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity) .
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. Avoid repeated freeze-thaw cycles.
Subcellular Location
Secreted.

UniProtKB · Q8R1R4

Interleukin-34

IL34_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q8R1R4
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Il34
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
IL-34
EC number
—
Processing
Precursor
Secondary accessions
B2ZC71, B2ZC72, Q9D8F2
Protein keywords

Technical term

3D-structureReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

CytokineGrowth factor

PTM

Glycoprotein

Biological process

ImmunityInflammatory responseInnate immunity

Cellular component

Secreted

Domain

Signal

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