OTUB1/USP8-IN-1

OTUB1/USP8-IN-1

• CAS Number: 2858800-98-1
• UNSPSC Description: OTUB1/USP8-IN-1 is a potent dual OTUB1/USP8 inhibitor with IC50 values of 0.17 and 0.28 nM for OTUB1 and USP8, respectively. OTUB1/USP8-IN-1 can be used in research of cancer[1].
• Target Antigen: Deubiquitinase
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/otub1-usp8-in-1.html
• Solubility: DMSO : 50 mg/mL (ultrasonic)|H2O : 4.07 mg/mL (ultrasonic;warming;adjust pH to 3 with 1 M HCL;heat to 60°C)
• Smiles: O=C(C1=C2OC(C3=C(F)C=CC(O[C@H]4CN(C)CC4)=C3Cl)=N1)C5=C(C=CC=C5)C2=O
• Molecular Weight: 426.82
• References & Citations: [1]Tan L, et, al. Discovery of Potent OTUB1/USP8 Dual Inhibitors Targeting Proteostasis in Non-Small-Cell Lung Cancer. J Med Chem. 2022 Oct 11.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported