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Crotamine

CAT: 0804-HY-P5159Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P5159Size:1 Each
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Description
Crotamine is a Na+ channel modulator. Crotamine is a 42 amino acid toxin cross-linked by three disulfide bridges. Crotamine has analgesic activity. Crotamine also interacts with lipid membranes and shows myonecrotic activity. Crotamine can be isolated from Crotalus durissus terrificus venom[1][2].
UNSPSC
12352209
Target
Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/crotamine.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H]1NC2=O)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(NCC(NCC(N[C@@H](CC4=CNC=N4)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@H]2CCCCN)=O)=O)=O)=O)=O)NC9=O)C(N[C@@H](CC%10=CC=CC=C%10)C(N%11[C@@H](CCC%11)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CO)C(NCC(O)=O)=O)=O)=O)=O)=O)NC1=O)C(N[C@@H](CC(C)C)C(N%12[C@@H](CCC%12)C(N%13[C@@H](CCC%13)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CC%14=CC=CC=C%14)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCSC)C(N[C@H]9CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC%15=CC=C(C=C%15)O)N
Molecular Formula
C214H326N64O54S7
Molecular Weight
4883.73
References & Citations
[1]Nicastro G, et al. Solution structure of crotamine, a Na+ channel affecting toxin from Crotalus durissus terrificus venom. Eur J Biochem. 2003 May;270 (9) :1969-79.|[2]Kerkis I, et al. Biological versatility of crotamine--a cationic peptide from the venom of a South American rattlesnake. Expert Opin Investig Drugs. 2010 Dec;19 (12) :1515-25.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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