Crotamine

• Description:

  Crotamine is a basic peptide present in the venom of the South American rattlesnake Crotalus durissus terrificus. Multiple biological functions have been attributed to Crotamine. It is a natural cell-penetrating peptide with selective biological action towards actively proliferating cell types. Moreover, it has been reported that crotamine is a blocker of Kv1.3 (IC50 around 300 nM) as well as Kv1.1 and Kv1.2. It has analgesic properties and myonecrotic effects. In addition, crotamine belongs to the beta-defensin peptides and as such demonstrates antibacterial properties by interacting with lipid membranes.

• Specifications:

  Blocker of Kv1.3, Kv1.1 and Kv1.2 channels / Cell Penetrating Peptide

• Target:

  Others

• Sequence:

  YKQCHKKGGHCFPKEKICLPPSSDFGKMDCRWRWKCCKKGSG

• Peptide Number:

  CRO001

• Disulfide Bonds:

  Cys4-Cys36; Cys11-Cys30; Cys18-Cys37

• N Terminal Sequence:

  H

• C Terminal Sequence:

  OH