P73 (Phospho-Tyr99) Colorimetric Cell-Based ELISA Kit

• Description:

  The p73 (Phospho-Tyr99) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor p73 (Phospho-Tyr99) protein expression profile in cells. The kit can be used for measuring the relative amounts of p73 (Phospho-Tyr99) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on p73 (Phospho-Tyr99) .

• Synonyms:

  Tumor protein p73; p53-like transcription factor; p53-related protein; TP73; P73

• Gene Name:

  TP73

• UniProt:

  O15350

• Reactivity:

  Human, Mouse

• Tissue Specificity:

  Expressed in striatal neurons of patients with Huntington disease (at protein level) . Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.

• Molecular Weight:

  69623 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Tumor protein p73

• Subcellular Location:

  Nucleus. Cytoplasm. Accumulates in the nucleus in response to DNA damage.