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PDCD4 (Phospho-Ser67) Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC2325Size: 1 Kit, Containing two 96 Well Plates and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC2325Size:1 Kit, Containing two 96 Well Plates and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The PDCD4 (Phospho-Ser67) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor PDCD4 (Phospho-Ser67) protein expression profile in cells. The kit can be used for measuring the relative amounts of PDCD4 (Phospho-Ser67) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on PDCD4 (Phospho-Ser67) .
Synonyms
Programmed cell death protein 4; Nuclear antigen H731-like; Neoplastic transformation inhibitor protein; Protein 197/15a; PDCD4; H731
Gene Name
PDCD4
UniProt
Q53EL6
Reactivity
Human, Mouse, Rat
Tissue Specificity
Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity) .
Molecular Weight
51735 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Programmed cell death protein 4
Subcellular Location
Nucleus. Cytoplasm. Shuttles between the nucleus and cytoplasm (By similarity) . Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133) .

UniProtKB · Q53EL6

Programmed cell death protein 4

PDCD4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q53EL6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PDCD4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2RCV4, B5ME91, O15501, Q5VZS6, Q6PJI5, Q8TAR5, Q99834
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

Apoptosis

Cellular component

CytoplasmNucleus

Domain

Repeat

Molecular function

RNA-binding

Disease

Tumor suppressor

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