BAD (Phospho-Ser134) Colorimetric Cell-Based ELISA Kit

• Description:

  The BAD (Phospho-Ser134) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor BAD (Phospho-Ser134) protein expression profile in cells. The kit can be used for measuring the relative amounts of BAD (Phospho-Ser134) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on BAD (Phospho-Ser134) .

• Synonyms:

  BAD; BBC6; Bcl- XL/Bcl-2 associated death promoter; Bcl-2 binding component 6; Bcl-2-like 8 protein; Bcl-xL/Bcl-2 associated death promoter; Bcl2-antagonist of cell death; BCL2L8

• Gene Name:

  BAD

• UniProt:

  Q92934

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Expressed in a wide variety of tissues.

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Promotes cell death. Successfully competes for the binding to Bcl-X (L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X (L), but not that of Bcl-2 (By similarity) . Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

• Molecular Weight:

  18392 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Bcl2-associated agonist of cell death

• Subcellular Location:

  Mitochondrion outer membrane. Cytoplasm. Colocalizes with HIF3A in the cytoplasm (By similarity) . Upon phosphorylation, locates to the cytoplasm.