BCAR1 (Phospho-Tyr410) Colorimetric Cell-Based ELISA Kit

• Description:

  The BCAR1 (Phospho-Tyr410) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor BCAR1 (Phospho-Tyr410) protein expression profile in cells. The kit can be used for measuring the relative amounts of BCAR1 (Phospho-Tyr410) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on BCAR1 (Phospho-Tyr410) .

• Synonyms:

  BCAR1; Breast cancer anti-estrogen resistance 1; CRK-ASSOCIATED SUBSTRATE; CRKAS

• Gene Name:

  BCAR1

• UniProt:

  P56945

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line.

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.

• Molecular Weight:

  93372 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Breast cancer anti-estrogen resistance protein 1

• Subcellular Location:

  Cell junction, focal adhesion. Cytoplasm. Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation.