TUSC3 Colorimetric Cell-Based ELISA

• Description:

  The TUSC3 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor TUSC3 protein expression profile in cells. The kit can be used for measuring the relative amounts of TUSC3 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on TUSC3.

• Synonyms:

  Tumor suppressor candidate 3; Magnesium uptake/transporter TUSC3; Protein N33; TUSC3; N33

• Gene Name:

  TUSC3

• UniProt:

  Q13454

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Expressed in most non-lymphoid cells and tissues examined, including prostate, lung, liver, colon, heart, kidney and pancreas.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition.

• Molecular Weight:

  39676 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Tumor suppressor candidate 3

• Subcellular Location:

  Endoplasmic reticulum membrane; Multi-pass membrane protein.