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PGP9.5 Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1454Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1454Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The PGP9.5 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor PGP9.5 protein expression profile in cells. The kit can be used for measuring the relative amounts of PGP9.5 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on PGP9.5.
Synonyms
Ubiquitin carboxyl-terminal hydrolase isozyme L1; UCH-L1;3.4.19.12;6.-.-.-; Neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; Ubiquitin thioesterase L1; UCHL1
Gene Name
UCHL1
UniProt
P09936
Reactivity
Human, Mouse, Rat
Tissue Specificity
Found in neuronal cell bodies and processes throughout the neocortex (at protein level) . Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
Molecular Weight
24824 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Subcellular Location
Cytoplasm. Endoplasmic reticulum membrane; Lipid-anchor. About 30% of total UCHL1 is associated with membranes in brain.

UniProtKB · P09936

Ubiquitin carboxyl-terminal hydrolase isozyme L1

UCHL1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P09936
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
UCHL1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
UCH-L1
EC number
3.4.19.12
Processing
Precursor
Secondary accessions
Q4W5K6, Q71UM0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationGlycoproteinLipoproteinOxidationPhosphoproteinPrenylation

Coding sequence diversity

Alternative initiation

Cellular component

CytoplasmEndoplasmic reticulumMembrane

Disease

Disease variantHereditary spastic paraplegiaNeurodegenerationParkinson diseaseParkinsonism

Molecular function

HydrolaseProteaseThiol protease

Biological process

Ubl conjugation pathway

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