PEA-15 Colorimetric Cell-Based ELISA Kit

• Description:

  The PEA-15 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor PEA-15 protein expression profile in cells. The kit can be used for measuring the relative amounts of PEA-15 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on PEA-15.

• Synonyms:

  Astrocytic phosphoprotein PEA-15;15 kDa phosphoprotein enriched in astrocytes; Phosphoprotein enriched in diabetes; PED; PEA15

• Gene Name:

  PEA15

• UniProt:

  Q15121

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose- producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity) . Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.

• Molecular Weight:

  15040 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Astrocytic phosphoprotein PEA-15

• Subcellular Location:

  Cytoplasm. Associated with microtubules.