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Granzyme B Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1249Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1249Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The Granzyme B Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Granzyme B protein expression profile in cells. The kit can be used for measuring the relative amounts of Granzyme B in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Granzyme B.
Synonyms
Granzyme B; Granzyme-2; T-cell serine protease 1-3E; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; SECT; Cathepsin G-like 1; CTSGL1; CTLA-1; Fragmentin-2; Human lymphocyte protein; HLP; C11
Gene Name
GZMB
UniProt
P10144
Reactivity
Human, Mouse, Rat
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Molecular Weight
27716 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Granzyme B
Subcellular Location
Cytoplasmic granule. Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.

UniProtKB · P10144

Granzyme B

GRAB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P10144
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GZMB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.79
Processing
Precursor
Secondary accessions
Q8N1D2, Q9UCC1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

ApoptosisCytolysis

PTM

Disulfide bondGlycoproteinZymogen

Molecular function

HydrolaseProteaseSerine protease

Cellular component

LysosomeSecreted

Domain

Signal

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