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ATP1A1 Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1045Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1045Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The ATP1A1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor ATP1A1 protein expression profile in cells. The kit can be used for measuring the relative amounts of ATP1A1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on ATP1A1.
Synonyms
A1A1; AT1A1; ATPase, Na+/K+ transporting, alpha 1 polypeptide; Hypothetical protein MGC38419; Na+/K+ ATPase 1; Na, K-ATPase 1; Sodium pump 1; Sodium/potassium-transporting ATPase alpha-1 chain precursor
Gene Name
ATP1A1
UniProt
P05023
Reactivity
Human, Mouse, Rat
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Molecular Weight
112896 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Sodium/potassium-transporting ATPase subunit alpha-1
Subcellular Location
Cell membrane, sarcolemma; Multi-pass membrane protein. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

UniProtKB · P05023

Sodium/potassium-transporting ATPase subunit alpha-1

AT1A1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P05023
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ATP1A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Na(+)/K(+) ATPase alpha-1 subunit
EC number
7.2.2.13
Processing
—
Secondary accessions
B2RBR6, B7Z2T5, B7Z3U6, F5H3A1, Q16689, Q6LDM4, Q9UCN1, Q9UJ20, Q9UJ21
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-bindingPotassiumSodium

Cellular component

Cell membraneCell projectionMembrane

Disease

Charcot-Marie-Tooth diseaseEpilepsyIntellectual disabilityNeurodegenerationNeuropathyPrimary hypomagnesemia

Biological process

Ion transportPotassium transportSodium transportSodium/potassium transportTransport

Molecular function

Translocase

Domain

TransmembraneTransmembrane helix

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