Anti-Human Lambda Light Chain Rabbit Monoclonal Antibody, Clone#RM127

• Description:

  Boster Bio Anti-Human Lambda Light Chain Rabbit Monoclonal Antibody, Clone#RM127 (Catalog # M12334) . Tested in ELISA, ICC, IHC, Flow Cytometry applications. This antibody reacts with Human.

• Synonyms:

  Immunoglobulin lambda constant 1 ; Ig lambda chain C region MGC ; Ig lambda-1 chain C region ; IGLC1

• Gene Name:

  IGLC1

• UniProt:

  P0CG04

• Host:

  Rabbit

• Reactivity:

  Human

• Cross Reactivity:

  This antibody reacts to the lambda light chain of human immunoglobulins, and does not react to the kappa light chain. RM127 does not react to monkey (Cyno or Rhesus) IgG, mouse IgG, rat IgG, or goat IgG.

• Immunogen:

  Human IgG

• Clonality:

  Monoclonal

• Clone:

  Clone: RM127

• Applications:

  ELISA, ICC, IHC, Flow Cytometry

• Field of Research:

  Immunoglobulins, Immunology

• Purification:

  Protein A affinity purified from an animal origin-free culture supernatant

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268) . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V- (D) -J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268) .

• Molecular Weight:

  11348 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Other Gene Names:

  Immunoglobulin lambda constant 1

• Subcellular Location:

  Secreted. Cell membrane.