Anti-A2M/Alpha 2 Macroglobulin Rabbit Monoclonal Antibody

Anti-A2M/Alpha 2 Macroglobulin Rabbit Monoclonal Antibody

• Description: Boster Bio Anti-A2M/Alpha 2 Macroglobulin Rabbit Monoclonal Antibody catalog # M01498. Tested in WB, IHC applications. This antibody reacts with Human.
• Synonyms: Alpha-2-macroglobulin;Alpha-2-M;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5;A2M;CPAMD5;FWP007;
• CAS Number: 9007-83-4
• Gene Name: Alpha-2-macroglobulin
• UniProt: P01023
• Host: Rabbit
• Reactivity: Human
• Immunogen: A synthesized peptide derived from human A2M
• Clonality: Monoclonal
• Clone: Clone: ABAO-1
• Applications: WB,IHC
• Purification: Affinity-chromatography
• Concentration: Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
• Form: Liquid
• Reconstitution: Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL
• Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
• Storage Conditions: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
• Calculated Molecular Weight: 163291 MW
• Observed Molecular Weight: 60 kDa
• Fragment: Rabbit IgG
• Applications Notes: WB 1:500-1:2000
  IHC 1:50-1:200