Anti-Alpha-2-macroglobulin A2M Antibody

• Description:

  Boster Bio Anti-Alpha-2-macroglobulin A2M Antibody catalog # A01498. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Alpha-2-macroglobulin; Alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; A2M; CPAMD5; FWP007;

• Gene Name:

  A2M

• UniProt:

  P01023

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide corresponding to residues in Human A2M.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Secreted in plasma.

• Applications:

  WB

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Dilution:

  WB: 1:500-1:1000

• Form:

  Liquid

• Function:

  Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced) . Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

• Molecular Weight:

  163291 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Alpha-2-macroglobulin

• Subcellular Location:

  Secreted

• Protein Name:

  Alpha-2-macroglobulin