Anti-TXNIP Monoclonal Antibody

• Description:

  Boster Bio Anti-TXNIP Monoclonal Antibody catalog # M01409. Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  RalA-binding protein 1; RalBP1;76 kDa Ral-interacting protein; Dinitrophenyl S-glutathione ATPase; DNP-SG ATPase; Ral-interacting protein 1; RALBP1; RLIP1, RLIP76

• Gene Name:

  RalA-binding protein 1

• UniProt:

  Q9H3M7

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthesized peptide derived from human TXNIP

• Clonality:

  Monoclonal

• Clone:

  Clone: AEBA-20

• Tissue Specificity:

  Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes. .

• Applications:

  WB, IHC, ICC, IF, Flow Cytometry

• Field of Research:

  Cancer, Cancer Metabolism, Cancer Susceptibility, Carbohydrate Metabolism, Cell Biology, Co-Activators/Co-Repressors, Energy Metabolism, Energy Transfer Pathways, Epigenetics and Nuclear Signaling, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism Of Carbohydrates, Nuclear Receptors, Nuclear Signaling Pathways, Oncoproteins/Suppressors, Oxidative Stress, Pathways and Processes, Redox Metabolism, Signal Transduction, Transcription, Tumor Suppressors

• Purification:

  Affinity-chromatography

• Concentration:

  Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Reconstitution:

  Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

• Function:

  Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S- (2,4-dinitrophenyl) -glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin. .

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  WB 1:500-1:2000
  IHC 1:50-1:200
  ICC/IF 1:50-1:200
  FC 1:100

• Other Gene Names:

  TXNIP

• Subcellular Location:

  Membrane ; Peripheral membrane protein .

• Protein Name:

  Glycogen synthase kinase-3 beta (gsk3b)