Anti-TXNIP Antibody

• Background:

  Thioredoxin-interacting protein (TXNIP) belongs to the arrestin family and plays a critical role in the antioxidant defense mechanisms of hematopoietic cells by activating the p53 pathway during oxidative stress (1, 2). It functions as a transcriptional repressor and acts as an oxidative stress mediator by inhibiting thioredoxin activity (2). TXNIP expression is reduced in many types of tumors, and TXNIP overexpression inhibits tumor growth by blocking cell-cycle progression (3). It has recently reported that TXNIP deficiency correlates with a high incidence of hepatocellular carcinoma (HCC) (4). TXNIP and p53 interactions could potentially be a therapeutic target for oxidative stress-related diseases such as hematopoietic malignancies and metabolic diseases (5).

• Description:

  Boster Bio Anti-TXNIP Antibody (Catalog # A01409). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Thioredoxin-interacting protein, BMP and activin membrane-bound inhibitor homolog, non-metastatic gene A protein, NMA

• Gene Name:

  TXNIP

• UniProt:

  Q9H3M7

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Cross Reactivity:

  TXNIP antibody is human, mouse and rat reactive.

• Immunogen:

  TXNIP antibody was raised against a 16 amino acid peptide near the center of human TXNIP. The immunogen is located within amino acids 110 - 160 of TXNIP.

• Clonality:

  Polyclonal

• Applications:

  ELISA, WB, IHC-P, IF

• Purification:

  TXNIP antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Molecular Weight:

  43661 MW

• Components:

  TXNIP antibody is supplied in PBS containing 0.02% sodium azide.

• Storage Conditions:

  TXNIP antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

• Fragment:

  IgG

• CAS Number:

  9007-83-4