Anti-TXNIP Antibody

• Background:

  Thioredoxin-interacting protein (TXNIP) belongs to the arrestin family and plays a critical role in the antioxidant defense mechanisms of hematopoietic cells by activating the p53 pathway during oxidative stress (1,2) . It functions as a transcriptional repressor and acts as an oxidative stress mediator by inhibiting thioredoxin activity (2) . TXNIP expression is reduced in many types of tumors, and TXNIP overexpression inhibits tumor growth by blocking cell-cycle progression (3) . It has recently reported that TXNIP deficiency correlates with a high incidence of hepatocellular carcinoma (HCC) (4) . TXNIP and p53 interactions could potentially be a therapeutic target for oxidative stress-related diseases such as hematopoietic malignancies and metabolic diseases (5) .

• Description:

  Boster Bio Anti-TXNIP Antibody (Catalog # A01409) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Thioredoxin-interacting protein, BMP and activin membrane-bound inhibitor homolog, non-metastatic gene A protein, NMA

• Gene Name:

  TXNIP

• UniProt:

  Q9H3M7

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Cross Reactivity:

  TXNIP antibody is human, mouse and rat reactive.

• Immunogen:

  TXNIP antibody was raised against a 16 amino acid peptide near the center of human TXNIP. The immunogen is located within amino acids 110 - 160 of TXNIP.

• Clonality:

  Polyclonal

• Applications:

  ELISA, WB, IHC-P, IF

• Field of Research:

  Cancer

• Purification:

  TXNIP antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) .

• Molecular Weight:

  43661 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  TXNIP antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

• Fragment:

  IgG

• Other Gene Names:

  Thioredoxin interacting protein

• Subcellular Location:

  Cytoplasm .

• Prediction Reactivity:

  Pig

• Protein Name:

  Thioredoxin interacting protein