Anti-Alpha-1-Antitrypsin (SERPINA1) (Hepatocellular & Histiocytic Marker) Monoclonal Antibody

• Background:

  The immunohistochemical staining of AAT is useful in identification of benign and malignant hepatic tumors and yolk sac carcinomas. Positive staining for AAT is also used in detection of benign and malignant lesions of histiocytic nature. This antibody is may also useful tool in the screening of patients with cryptogenic cirrhosis or other forms of liver disease with fibrosis of uncertain origin.

• Description:

  Boster Bio Anti-Alpha-1-Antitrypsin (SERPINA1) (Hepatocellular & Histiocytic Marker) Monoclonal Antibody (Catalog # M00720) . Tested in WB, IHC applications. This antibody reacts with Human.

• Synonyms:

  Alpha-1-antitrypsin; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1; Short peptide from AAT; SPAAT; SERPINA1; AAT, PI; PRO0684, PRO2209

• Gene Name:

  SERPINA1

• UniProt:

  P01009

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Recombinant human Alpha-1-Antitrypsin (AAT) protein fragment

• Clonality:

  Monoclonal

• Clone:

  Clone: Clone: AAT/1379

• Tissue Specificity:

  Ubiquitous. Expressed in leukocytes and plasma. .

• Applications:

  WB, IHC

• Field of Research:

  Apoptosis, Cancer, Cancer Metabolism, Cardiovascular, Cell Biology, Intracellular, Kinases, Metabolism, Metabolism Processes, Pathways and Processes, Protease Inhibitors, Proteolysis/Ubiquitin, Response To Hypoxia, Serum Proteins

• Purification:

  200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.

• Concentration:

  Purified antibody with BSA and azide at 200ug/ml

• Form:

  Liquid

• Function:

  Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.

• Molecular Weight:

  46737 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Fragment:

  IgG1, kappa

• Other Gene Names:

  Alpha-1-antitrypsin

• Subcellular Location:

  Cytoplasmic