Anti-PI 3 Kinase p85 alpha PIK3R1 Rabbit Monoclonal Antibody

• Description:

  Boster Bio Anti-PI 3 Kinase p85 alpha PIK3R1 Rabbit Monoclonal Antibody catalog # M00318. Tested in WB application. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha; PIK3R1; GRB1

• Gene Name:

  Phosphatidylinositol 3-kinase regulatory subunit alpha

• UniProt:

  P27986

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthesized peptide derived from human PI 3 Kinase p85 alpha

• Clonality:

  Monoclonal

• Clone:

  Clone: CGB-16

• Tissue Specificity:

  Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level) . .

• Applications:

  WB

• Field of Research:

  Stem Cells

• Purification:

  Affinity-chromatography

• Concentration:

  Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Reconstitution:

  Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

• Function:

  Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429) . Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923) . .

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  WB 1:500-1:2000

• Other Gene Names:

  PIK3R1

• Subcellular Location:

  Cell membrane ; Lipid-anchor, GPI-anchor . Secreted . Locates to the plasma membrane of microvilli of hepatocytes with triacyl- glycerol-rich lipoproteins (TRL) . Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles (By similarity) . .

• Protein Name:

  P2X purinoceptor 1