Anti-KAPCB PRKACB Antibody

• Background:

  Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
  
  Beebe S.J., Mol. Endocrinol. 4:465-475(1990).
  Gregory S.G., Nature 441:315-321(2006).
  Wu K.-J., Oncogene 21:7872-7882(2002).

• Description:

  Boster Bio Anti-KAPCB PRKACB Antibody (Catalog # A05366) . Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  CAMP-dependent protein kinase catalytic subunit beta; PKA C-beta;2.7.11.11; PRKACB

• Gene Name:

  PRKACB

• UniProt:

  P22694

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthesized peptide derived from internal of human KAPCB.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain. .

• Applications:

  WB

• Field of Research:

  Cancer, Cancer Metabolism, Energy Transfer Pathways, Integration Of Energy, Integration Of Energy Metabolism, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Nucleotide Messenger, Pathways and Processes, Protein Phosphorylation, Second Messenger, Ser/Thr Kinases, Signal Transduction

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Dilution:

  Western blotting: 1:500~1:3000

• Form:

  Liquid

• Function:

  Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. .

• Molecular Weight:

  40623 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  CAMP-dependent protein kinase catalytic subunit beta

• Subcellular Location:

  Cytoplasm . Cell membrane . Membrane ; Lipid-anchor . Nucleus . Translocates into the nucleus (monomeric catalytic subunit) . The inactive holoenzyme is found in the cytoplasm. .