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Anti-MARK4 Antibody

CAT: 0519-A04672-1Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A04672-1Size:100 µL
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Description
Boster Bio Anti-MARK4 Antibody (Catalog# A04672-1) . Tested in IF, ICC, ELISA applications. This antibody reacts with Human, Mouse.
Synonyms
MARK4; KIAA1860; MARKL1; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase-like 1
Gene Name
MARK4
UniProt
Q96L34
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A peptide derived from human MARK4. Immunogen sequence location: 461-510
Clonality
Polyclonal
Tissue Specificity
Ubiquitous. Isoform 2 is brain-specific (PubMed:11326310) . Expressed at highest levels in brain and testis. Also expressed in heart, lung, liver, muscle, kidney and spleen (PubMed:14594945) .
Applications
IF, ICC, ELISA
Field of Research
Cytoskeleton, Cytoskeleton/ECM, Microtubules, Signal Transduction
Purification
The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
Concentration
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Form
Liquid
Function
Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942) . Phosphorylates the microtubule-associated protein MAPT (PubMed:14594945, PubMed:23666762) . Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945) . Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532) . Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999) . Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999) . Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532) . Reduces neuronal cell survival (PubMed:15009667) . Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity) . Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity) . Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942) .
Molecular Weight
82520 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
Rabbit IgG
Other Gene Names
MAP/microtubule affinity-regulating kinase 4
Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.Cytoplasm, cytoskeleton, microtubule organizing center.Cytoplasm, cytoskeleton, cilium basal body.Cytoplasm, cytoskeleton, cilium axoneme.Cytoplasm. Localized at the tips of neurite-like processes in differentiated neuroblast cells. Detected in the cytoplasm and neuropil of the hippocampus.

UniProtKB · Q96L34

MAP/microtubule affinity-regulating kinase 4

MARK4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96L34
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MARK4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
Q8NG37, Q96JG7, Q96SQ2, Q9BYD8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell cycleCell divisionCilium biogenesis/degradationMitosis

Cellular component

Cell projectionCytoplasmCytoskeleton

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

PhosphoproteinUbl conjugation

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