Anti-GIT1 Antibody

• Background:

  GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes.
  
  Premont R.T., J. Biol. Chem. 275:22373-22380(2000).
  The MGC Project Team, Genome Res. 14:2121-2127(2004).
  Premont R.T., Proc. Natl. Acad. Sci. U.S.A. 95:14082-14087(1998).

• Description:

  Boster Bio Anti-GIT1 Antibody (Catalog # A02140) . Tested in WB, IHC applications. This antibody reacts with Human.

• Synonyms:

  ARF GTPase-activating protein GIT1; ARF GAP GIT1; Cool-associated and tyrosine-phosphorylated protein 1; CAT-1; CAT1; G protein-coupled receptor kinase-interactor 1; GRK-interacting protein 1; GIT1

• Gene Name:

  GIT1

• UniProt:

  Q9Y2X7

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Synthesized peptide derived from C-terminal of human GIT1.

• Clonality:

  Polyclonal

• Applications:

  WB, IHC

• Field of Research:

  Adapters, Cytoplasmic, G Protein Signaling, Protein Trafficking, Signal Transduction, Signaling Pathway, Vesicle Transport

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve SDCCAG3 and PTPN13 (By similarity) . .

• Molecular Weight:

  84341 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  ARF GTPase-activating protein GIT1

• Subcellular Location:

  Cytoplasm . Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytoplasmic complexes and membrane protrusions. During cell migration, when cells detach, moves from the adhesions into the cytoplasmic complexes towards the leading edge, while, when cells adhere, it is found in vinculin-containing adhesions. Recruitment to adhesions may be mediated by active tyrosine-phosphorylated paxillin.