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Anti-RING1B RNF2 Antibody

CAT: 0519-A01209-1Size: 100 µgDry Ice: YesHazardous: No
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CAT#:0519-A01209-1Size:100 µg
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Background
RING1B (also known as BAP1 and RNF2) is one of the PcG proteins. The polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2) . Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), a ubiquitin-conjugating enzyme that possesses ubiquitin ligase activity. Anti-RINGB1 Antibody is useful for researchers interested in epigenetics, ubiquitin, and transcription factor research.
Description
Boster Bio Anti-RING1B RNF2 Antibody (Catalog # A01209-1) . Tested in ELISA, IF, WB applications. This antibody reacts with Human, Mouse, Chinese Hamster.
Synonyms
RING1B, RING finger protein BAP1, DING, RING finger protein 1B, E3 ubiquitin protein ligase RING 2, Huntingtin interacting protein 2 interacting protein 3, Anti-RNF2, HIP2-interacting protein 3, Protein DinG
Gene Name
RNF2
UniProt
Q99496
Host
Goat
Reactivity
Chinese hamster, Human, Mouse
Immunogen
RING1B Antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region near aa 180-205 of human RING1B protein.
Clonality
Polyclonal
Applications
ELISA, IF, WB
Field of Research
2339, Chromatin Remodeling, Epigenetics and Nuclear Signaling
Purification
Affinity purified Anti-RING1B antibody is directed against human RING1B protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest reactivity with this protein from human, chimpanzee, orangutan, mouse, rat, dog, bovine, frog and chicken based on 100% homology for the immunogen sequence. Expect cross-reactivity with RING1B from zebrafish, as only a single amino acid residue changes within the immunogen sequence (92% positive by BLAST) . Cross-reactivity with RING1B homologues from other sources has not been determined.
Concentration
1.1 mg/mL by UV absorbance at 280 nm
Form
Liquid (sterile filtered)
Shipping Conditions
Due to dry ice shipping issues, this product is temporarily not available to distributors outside of the United States.
Storage Conditions
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
Fragment
IgG
Applications Notes
Anti-RING1B purified antibody has been tested for use in ELISA, immunofluorescence, and by western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 38 kDa in size corresponding to RING1B by western blotting in the appropriate cell lysate or extract.

UniProtKB · Q99496

E3 ubiquitin-protein ligase RING2

RING2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q99496
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RNF2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.27
Processing
—
Secondary accessions
B2RBS7, B3KRH1, Q5TEN1, Q5TEN2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Cellular component

ChromosomeCytoplasmNucleus

Disease

Disease variantEpilepsyIntellectual disability

Ligand

Metal-bindingZinc

Molecular function

RepressorTransferase

Biological process

TranscriptionTranscription regulationUbl conjugation pathway

Domain

Zinc-finger

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