Rat GFRA2 ELISA Kit PicoKine®

Rat GFRA2 ELISA Kit PicoKine®

• Background: GDNF family receptor alpha-2 (GFRα2), also known as the neurturin receptor, is a protein that in humans is encoded by the GFRA2 gene. It is mapped to 15p11. The GFRA2 protein is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. They both bind the GFRA2 receptor. The receptor mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. GFRA2 (gene) has been shown to interact with GDNF.
• Description: Rat GFRA2 ELISA Kit PicoKine® (96 Tests). Quantitate Rat Gfra2 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 50pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.
• Synonyms: GDNF family receptor alpha; Gfra2; GDNFR-beta; rCG_37079
• CAS Number: 7732-18-5
• Gene Name: GDNF family receptor alpha 2
• Gene ID: 25136
• UniProt: O35977
• Reactivity: Rat
• Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.
• Immunogen: Expression system for standard: NS0; Immunogen sequence: S22-S443
• Applications: ELISA
• Detection Range: 312 pg/ml - 20,000 pg/ml
• : heparin, EDTA or citrate
• Sample Type: cell culture supernatants, serum and plasma (heparin, EDTA, citrate).
• Sensitivity: <50 pg/ml
• Storage Conditions: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
• Reproducibility:

  Lots	Lot 1 (pg/ml)	Lot 2 (pg/ml)	Lot 3 (pg/ml)	Lot 4 (pg/ml)	Mean (pg/ml)	Standard Deviation	CV (%)
  Sample 1	478	504	491	512	496	12.93	2.6%
  Sample 2	1856	1844	1896	2084	1920	96.62	5.0%
  Sample 3	5549	5354	6042	6100	5761	317.99	5.5%

  *number of samples for each test n=16.
• Specificity: Natural and recombinant rat GFRA2