Mouse N-Cadherin-2 CDH2 CD325 ELISA Kit PicoKine®

• Background:

  Cadherin-2 (CDH2), also known as neural cadherin (NCAD), is a protein that in humans is encoded by the CDH2 gene. It is a classical cadherin from the cadherin superfamily. This gene is mapped to 18q12.1. Cadherin-2 is expressed in the brain, skeletal and cardiac muscle. Cadherin-2 is commonly found in cancer cells and provides a mechanism for transendothelial migration. It is a calcium dependent cell-cell adhesion glycoprotein comprising five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

• Description:

  Mouse N-Cadherin-2 CDH2 CD325 ELISA Kit PicoKine® (96 Tests) . Quantitate Mouse Cdh2 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA) . Sensitivity: 20pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

• Synonyms:

  Cadherin-2; Neural cadherin; N-cadherin; CD325; Cdh2

• Gene Name:

  Cadherin-2

• UniProt:

  P15116

• Reactivity:

  Mouse

• Cross Reactivity:

  There is no detectable cross-reactivity with other relevant proteins.

• Immunogen:

  Expression system for standard: NS0; Immunogen sequence: D160-A724

• Applications:

  ELISA

• Field of Research:

  Cadherins, Cell Adhesion, Cytoskeleton/ECM, Signal Transduction

• Sample Type:

  Cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA) .

• Detection Range:

  0.78 ng/ml - 50 ng/ml

• Sensitivity:

  <20 pg/ml

• Function:

  Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence (PubMed:24952463) . CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. .

• Storage Conditions:

  Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

• Other Gene Names:

  CDH2

• Subcellular Location:

  Cell membrane; Single-pass type I membrane protein.

• Protein Name:

  Cadherin-2