Human TFPI / Tissue Factor Pathway Inhibitor ELISA Kit PicoKine®

• Background:

  TFPI (Tissue factor pathway inhibitor), also known as EPI, LACI or TFPI1, is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa) . The gene for TFPI is located on chromosome 2q31-q32.1, and has nine exons which span 70 kb. TFPI consists of a highly negatively-charged amino-terminus, three tandemly-linked Kunitz domains, and a highly positively-charged carboxy-terminus.TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM.

• Description:

  Human TFPI / Tissue Factor Pathway Inhibitor ELISA Kit PicoKine® (96 Tests) . Quantitate Human TFPI in cell culture supernatants, serum, plasma (heparin, EDTA, citrate) and urine. Sensitivity: 10pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

• Synonyms:

  Tissue factor pathway inhibitor; TFPI; Extrinsic pathway inhibitor; EPI; Lipoprotein-associated coagulation inhibitor; LACI; TFPI; LACI, TFPI1

• Gene Name:

  Tissue factor pathway inhibitor

• UniProt:

  P10646

• Reactivity:

  Human

• Cross Reactivity:

  There is no detectable cross-reactivity with other relevant proteins.

• Immunogen:

  Expression system for standard: NS0; Immunogen sequence: D29-K282

• Tissue Specificity:

  Mostly in endothelial cells.

• Applications:

  ELISA

• Field of Research:

  Cardiovascular, Platelets

• Sample Type:

  Cell culture supernatants, serum, plasma (heparin, EDTA, citrate) and urine.

• Detection Range:

  31.2 pg/ml - 2,000 pg/ml

• Sensitivity:

  <10 pg/ml

• Function:

  Inhibits factor X (X (a) ) ly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.

• Storage Conditions:

  Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

• Other Gene Names:

  TFPI

• Subcellular Location:

  Isoform Alpha: Secreted.

• Sequence Similarities:

  Contains 3 BPTI/Kunitz inhibitor domains.

• Protein Name:

  Tissue factor pathway inhibitor