Human CXCL7/PPBP/NAP-2 ELISA Kit PicoKine®

• Background:

  Chemokine (C-X-C motif) ligand 7 (CXCL7), also called PPBP or SCYB7, is a human gene. The encoded protein, Chemokine (C-X-C motif) ligand is a small cytokine belonging to the CXC chemokine family. CXCL7 is mapped to 4q13.3. It is a protein that is released in large amounts from platelets following their activation. CXCL7 is the precursor of the 2 platelet alpha-granule proteins, platelet basic protein (PBP) and connective tissue-activating peptide III (CTAP3) . It stimulates various processes including mitogenesis, synthesis of extracellular matrix, glucose metabolism and synthesis of plasminogen activator. It also stimulates the formation and secretion of plasminogen activator by synovial cells.

• Description:

  Human CXCL7/NAP-2 ELISA Kit PicoKine® (96 Tests) . Quantitate Human PPBP in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA) . Sensitivity: 2pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

• Synonyms:

  Platelet basic protein; PBP; C-X-C motif chemokine 7; Leukocyte-derived growth factor; LDGF; Macrophage-derived growth factor; MDGF; Small-inducible cytokine B7; Connective tissue-activating peptide III; CTAP-III; LA-PF4; Low-affinity platelet factor IV; TC-2; Connective tissue-activating peptide III (1-81) ; CTAP-III (1-81) ; Beta-thromboglobulin; Beta-TG; Neutrophil-activating peptide 2 (74) ; NAP-2 (74) ; Neutrophil-activating peptide 2 (73) ; NAP-2 (73) ; Neutrophil-activating peptide 2; NAP-2; TC-1; Neutrophil-activating peptide 2 (1-66) ; NAP-2 (1-66) ; Neutrophil-activating peptide 2 (1-63) ; NAP-2 (1-63) ; PPBP; CTAP3, CXCL7, SCYB7, TGB1, THBGB1

• Gene Name:

  Platelet basic protein

• UniProt:

  P02775

• Reactivity:

  Human

• Cross Reactivity:

  There is no detectable cross-reactivity with other relevant proteins.

• Immunogen:

  Expression system for standard: E.coli; Immunogen sequence: A59-D128

• Applications:

  ELISA

• Field of Research:

  Cardiovascular, Chemokines, Immunology, Innate Immunity, Platelets

• Sample Type:

  Cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA) .

• Detection Range:

  15.6 pg/ml - 1,000 pg/ml

• Sensitivity:

  <2 pg/ml

• Function:

  LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2 (73), NAP-2 (74), NAP-2 (1-66), and most potent NAP-2 (1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III (1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. .

• Storage Conditions:

  Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

• Other Gene Names:

  CXCL7

• Subcellular Location:

  Secreted.

• Sequence Similarities:

  Belongs to the intercrine alpha (chemokine CxC) family.

• Protein Name:

  Platelet basic protein