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Recombinant Human NAP-2 (PPBP) (CXCL7)

CAT: 0171-Z100729Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0171-Z100729Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The chemokine neutrophil- activating peptide 2 (NAP-2) is a 70-amino acid residue polypeptide that is formed from platelet-derived precursors by proteolytic processing. Mature NAP-2 stimulates various effector functions of polymorphonuclear neutrophil granulocytes (PMN) including directed chemotactic migration, exocytosis of lysosomal enzymes and secondary granule contents, and up-regulation of adhesion receptors. NAP-2 has been assigned to a subfamily now termed alpha-chemokines. The alpha-chemokines contain four cysteine residues at highly conserved positions which enclose the core region of the molecules. The first two cysteines are separated by a single amino acid, forming a motif (CXC) that distinguishes the alpha-chemokine from the beta-chemokine subfamily, where these cysteines are in directly adjacent position.
CAS Number
9000-83-3
Gene Name
PPBP
Gene Aliases
CXCL7, PBP (parent molecule), NAP2, CTAP-III (precursor), Platelet basic protein, C-X-C motif chemokine 7, Leukocyte-derived growth factor, LDGF, Macrophage-derived growth factor, MDGF, Small-inducible cytokine B7, SCYB7, TGB1, THBGB1
Recombinant Human Neutrophil Activating Peptide-2 (PPBP)
Gene ID
5473
Accession Number
P02775
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Solubility
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Function
Determined by its ability to chemoattract human monocytes using a concentration range of 2.0-40.0 ng/mL.
Molecular Weight
8
Shipping Conditions
Ambient Temperature
Storage Conditions
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Appearance
Lyophilized Powder
Formulation
Recombinant NAP-2 was lyophilized from a 0.2 μm filtered 20 mM PB,100 mM NaCl solution pH 7.5.

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Alternative Products

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MBS4159699-01Recombinant Human NAP-2 (PPBP) (CXCL7)
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