Anti-Human TCP1 alpha DyLight® 550 conjugated Antibody (monoclonal, 2E7)

• Background:

  T-complex protein 1 subunit alpha is a protein that in humans is encoded by the TCP1 gene. The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC) . This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found.

• Description:

  Boster Bio Anti-Human TCP1 alpha DyLight® 550 conjugated Antibody (monoclonal, 2E7) catalog # M02389-Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.

• Synonyms:

  T-complex protein 1 subunit alpha; TCP-1-alpha; CCT-alpha; TCP1; CCT1; CCTA

• Gene Name:

  T-complex 1

• UniProt:

  P17987

• Host:

  Mouse

• Reactivity:

  Human

• Cross Reactivity:

  No cross-reactivity with other proteins.

• Immunogen:

  A synthetic peptide corresponding to a sequence at the C-terminus of human TCP1 alpha, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.

• Clonality:

  Monoclonal

• Clone:

  Clone: Clone: 2E7

• Conjugation:

  DyLight®550

• Applications:

  Flow Cytometry

• Field of Research:

  Actin, Actin, etc., Chaperones, Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Protein Trafficking, Signal Transduction

• Concentration:

  0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Function:

  Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

• Storage Conditions:

  At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

• Fragment:

  Mouse IgG1

• Applications Notes:

  6

• Other Gene Names:

  TCP1

• Subcellular Location:

  Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.