Anti-Human PDCD10 DyLight® 550 conjugated Antibody

• Background:

  Programmed cell death protein 10 is a protein that in humans is encoded by the PDCD10 gene. This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.

• Description:

  Boster Bio Anti-Human PDCD10 DyLight® 550 conjugated Antibody catalog # A01879-Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.

• Synonyms:

  Programmed cell death protein 10; Cerebral cavernous malformations 3 protein; TF-1 cell apoptosis-related protein 15; PDCD10; CCM3; TFAR15

• Gene Name:

  Programmed cell death 10

• UniProt:

  Q9BUL8

• Host:

  Rabbit

• Reactivity:

  Human

• Cross Reactivity:

  No cross-reactivity with other proteins.

• Immunogen:

  E. coli-derived human PDCD10 recombinant protein (Position: M1-A212) .

• Clonality:

  Polyclonal

• Conjugation:

  DyLight®550

• Tissue Specificity:

  Ubiquitous.

• Applications:

  Flow Cytometry

• Field of Research:

  Apoptosis, Associated Proteins, Cell Biology, Developmental Biology, Intracellular, Neurogenesis, Neurology Process, Neuroscience, Organogenesis, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

• Concentration:

  0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Function:

  Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006) . Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed:27807006) . Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity) .

• Storage Conditions:

  At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

• Fragment:

  Rabbit IgG

• Applications Notes:

  6

• Other Gene Names:

  PDCD10

• Subcellular Location:

  Cytoplasm. Golgi apparatus membrane; Partially co- localizes with endogenous PXN at the leading edges of migrating cells.