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GM-90257

CAT: 0804-HY-155956-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-155956-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GM-90257 is a microtubule acetylation inhibitor. GM-90257 binds directly to α-tubulin. GM-90257 prevents the recruitment of α-tubulin acetyltransferase 1 (αTAT1) to the K40 residue in α-tubulin. GM-90257 causes Apoptosis, downregulates BCl-2, and activates JNK and PARP. GM-90257 has anticancer activity against breast cancer[1][2].
CAS Number
315703-81-2
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; JNK; Microtubule/Tubulin; PARP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; MAPK/ERK Pathway
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gm-90257.html
Purity
99.90
Smiles
CC(N=C1SC=CN12)=C2C3=CSC(NC4=CC=C(C=C4)OC)=N3
Molecular Formula
C16H14N4OS2
Molecular Weight
342.44
References & Citations
[1]Ahreum Kwon, et al. Potent Small-Molecule Inhibitors Targeting Acetylated Microtubules as Anticancer Agents Against Triple-Negative Breast Cancer. Biomedicines. 2020 Sep 9;8 (9) :338. |[2]Ahn S, et al. Microtubule Acetylation-Specific Inhibitors Induce Cell Death and Mitotic Arrest via JNK/AP-1 Activation in Triple-Negative Breast Cancer Cells. Mol Cells. 2023 Jun 30;46 (6) :387-398.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2

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