Mefenidil

CAT: 0804-HY-105925-01Size: 1 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-105925-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Mefenidil (MCN 2378) is a selective cerebral vasodilator that is not affected by beta-adrenergic blockade. Mefenidil can be used in the study of cardiovascular disease. In monkey models, mefenidil preferentially increases cerebral blood flow over systemic (femoral) blood flow. Mefenidil is also able to reduce systemic arterial pressure in anesthetized dogs.

CAS Number

58261-91-9

Product Name Alternative

MCN 2378

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/mefenidil.html

Solubility

10 mM in DMSO

Smiles

N#CCC1=C(C)N=C(C2=CC=CC=C2)N1

Molecular Formula

C12H11N3

Molecular Weight

197.24

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Hageman WE, et al. Cardiovascular profile of 5-methyl-2-phenyl-4-imidazole-acetonitrile (MCN-2378), a cerebral vasodilator. Eur J Pharmacol. 1975 Jan;30 (1) :100-6.|[2]Cardiovascular profile of 5-methyl-2-phenyl-4-imidazole-acetonitrile (MCN-2378), a cerebral vasodilator

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

Mefenidil

Mefenidil is a small molecule drug. The usage of the INN stem '-dil' in the name indicates that Mefenidil is a vasodilator. Mefenidil has a monoisotopic molecular weight of 197.1 Da.

CAS Number	58261-91-9
PubChem CID	65475
IUPAC Name	2-(5-methyl-2-phenyl-1H-imidazol-4-yl)acetonitrile
Molecular Formula	C12H11N3
Molecular Weight	197.24
XLogP	1.8
Topological Polar Surface Area	52.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Heavy Atom Count	15
Formal Charge	0
Complexity	249

SMILES

CC1=C(N=C(N1)C2=CC=CC=C2)CC#N

InChI

InChI=1S/C12H11N3/c1-9-11(7-8-13)15-12(14-9)10-5-3-2-4-6-10/h2-6H,7H2,1H3,(H,14,15)

InChIKey

OTRQRKIYHATFKM-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 58261-91-9

CID: 65475

Formula: C12H11N3

MW: 197.24

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	197.24
XLogP3	1.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	197.095297364
Monoisotopic Mass	197.095297364
Topological Polar Surface Area	52.5 Å²
Heavy Atom Count	15
Formal Charge	0
Complexity	249
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
GTR19194090-01	Mefenidil
AR-M04113-01	N-Nitroso Mefenidil

Mefenidil

Chemical Information

Alternative Products

Popular Products