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Belzutifan

CAT: 0804-HY-125840-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-125840-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Belzutifan (PT2977) is an orally active and selective HIF-2α inhibitor with an IC50 of 9 nM. Belzutifan, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. Belzutifan is a potential treatment for clear cell renal cell carcinoma (ccRCC) [1].
CAS Number
1672668-24-4
Product Name Alternative
PT2977; MK-6482
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pt2977.html
Concentration
10mM
Purity
99.85
Solubility
Acetone : 50 mg/mL (ultrasonic) |DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#CC1=CC(F)=CC(OC2=CC=C(S(=O)(C)=O)C3=C2[C@@H](F)[C@@H](F)[C@H]3O)=C1
Molecular Formula
C17H12F3NO4S
Molecular Weight
383.34
Precautions
H315, H319, H320
References & Citations
[1]Xu R, et al. 3-[ (1S,2S,3R) -2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma. J Med Chem. 2019 Aug 8;62 (15) :6876-6893.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched

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