FR-181877

• Description:

  FR-181877 (compound 4) is a non-prostaglandin PGI2 agonist. FR-181877 inhibits ADP (HY-W010918) -induced human platelet aggregation with an IC50 value of 0.081 μM[1].

• UNSPSC:

  12352005

• Target:

  Prostaglandin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/fr-181877.html

• Smiles:

  OC(COC1=C(CC2)C(C[C@H]2CN(C(C=C3)=O)N=C3C(C4=CC=CC=C4)C5=CC=CC=C5)=CC=C1)=O

• Molecular Formula:

  C30H28N2O4

• Molecular Weight:

  480.55

• References & Citations:

  [1]Tsubaki K, et al. A novel pyridazinone derivative as a nonprostanoid PGI2 agonist[J]. Bioorganic & medicinal chemistry letters, 2000, 10 (24) : 2787-2790.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [172936-99-1]