Valsartan methyl ester (Standard)

• UNSPSC Description:

  Valsartan methyl ester (Standard) is the analytical standard of Valsartan methyl ester. This product is intended for research and analytical applications. Valsartan methyl ester (Compound 3) is a derivative of Valsartan (HY-18204). Valsartan methyl ester is an orally active antagonist for angiotensin II, that inhibits angiotensin II (IC50 of 0.06 μM), angiotensin II-induced pressor response in rabbit aorta (IC50 of 0.068 μM) and angiotensin II-induced pressor response in the pithed rat model (10% inhibition at 10 mg/kg, p.o.)[1].

• Target Antigen:

  Angiotensin Receptor

• Type:

  Reference Standards

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/valsartan-methyl-ester-standard.html

• Smiles:

  COC([C@H](C(C)C)N(C(CCCC)=O)CC1=CC=C(C=C1)C2=C(C3=NN=NN3)C=CC=C2)=O

• Molecular Weight:

  449.55

• References & Citations:

  [1]Bühlmayer P, et al., Valsartan, a potent, orally active angiotensin II antagonist developed from the structurally new amino acid series[J]. Bioorganic & Medicinal Chemistry Letters, 1994, 4(1): 29-34.

• Shipping Conditions:

  Room temperature

• CAS Number:

  137863-17-3