Valsartan-d3

• Description :

  Valsartan-d3 is the deuterium labeled Valsartan[1]. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research[2].

• CAS Number :

  [1331908-02-1]

• Product Name Alternative :

  CGP 48933-d3

• UNSPSC :

  12352005

• Hazard Statement :

  H360, H412

• Target :

  Angiotensin Receptor

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  GPCR/G Protein

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Purity :

  94.36

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C)[C@@H](C(O)=O)N(C(CCCC([2H])([2H])[2H])=O)CC1=CC=C(C=C1)C2=C(C3=NN=NN3)C=CC=C2

• Molecular Formula :

  C24H26D3N5O3

• Molecular Weight :

  438.54

• Precautions :

  H360, H412

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Shan H, et al. Valsartan ameliorates ageing-induced aorta degeneration via angiotensin II type 1 receptor-mediated ERK activity. J Cell Mol Med. 2014 Jun;18 (6) :1071-80.|[3]Wang Y, et al. Valsartan blocked alcohol-induced, Toll-like receptor 2 signaling-mediated inflammation in human vascular endothelial cells. Alcohol Clin Exp Res. 2014 Oct;38 (10) :2529-40.|[4]Sui X, et al. Novel mechanism of cardiac protection by valsartan: synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated fibrosis after myocardial infarction. J Cell Mol Med. 2015 Aug;19 (8) :1773-82.|[5]Jiang Y, et al. Cardioprotective effect of valsartan in mice with short-term high-salt diet by regulating cardiac aquaporin 1 and angiogenic factor expression. Cardiovasc Pathol. 2015 Jul-Aug;24 (4) :224-9.|[6]Ping G, et al. Valsartan reverses depressive/anxiety-like behavior and induces hippocampal neurogenesis and expression of BDNF protein in unpredictable chronic mild stress mice. Pharmacol Biochem Behav. 2014 Sep;124:5-12.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported