JAK3 covalent inhibitor-2
CAT:
804-HY-161354
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
JAK3 covalent inhibitor-2
- CAS Number: 2664050-97-7
- UNSPSC Description: JAK3 covalent inhibitor-2 (compound J1b) is a selective, orally potent JAK3 inhibitor (IC50=7.2 nM) with low toxicity, anti-inflammatory activity and good bioavailability[1].
- Target Antigen: Apoptosis; JAK
- Type: Reference compound
- Related Pathways: Apoptosis;Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/jak3-covalent-inhibitor-2.html
- Solubility: 10 mM in DMSO
- Smiles: [O-][N+](C1=CC=CC(C2=CNC3=NC=NC(N4C[C@H](NC(C=C)=O)CCC4)=C32)=C1)=O
- Molecular Weight: 392.41
- References & Citations: [1]Hualiang Y et al. Design and synthesis of highly selective Janus kinase 3 covalent inhibitors for the treatment of rheumatoid arthritis ARCH PHARM. 2024 Feb e2300753
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported