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Griseofulvin

CAT: 0804-HY-17583-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17583-01Size:500 mg
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Description
Griseofulvin is an orally active antifungal antibiotic with antitumor activity. Griseofulvin induces apoptosis and G2/M cell cycle arrest in cancer cells. Griseofulvin also has cardiovascular modulatory activity, reducing angina pectoris, relieving hand artery spasm associated with onychomycosis, and peripheral vascular diseases such as shoulder-hand syndrome[1][2][3][4][5][6].
CAS Number
126-07-8
UNSPSC
12352005
Hazard Statement
H317, H351, H360
Target
Antibiotic; Apoptosis; Bcl-2 Family; Caspase; Endogenous Metabolite; Fungal; Microtubule/Tubulin; Wee1
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Griseofulvin.html
Purity
99.07
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C1[C@]2(C(OC)=CC(C[C@H]2C)=O)OC3=C(Cl)C(OC)=CC(OC)=C13
Molecular Formula
C17H17ClO6
Molecular Weight
352.77
Precautions
H317, H351, H360
References & Citations
[1]Brilhante RSN, et al. In vitro activity of azole derivatives and griseofulvin against planktonic and biofilm growth of clinical isolates of dermatophytes. Mycoses. 2018 Jul;61 (7) :449-454.|[2]Schmeel LC, et al. Griseofulvin Efficiently Induces Apoptosis in In Vitro Treatment of Lymphoma and Multiple Myeloma. Anticancer Res. 2017 May;37 (5) :2289-2295.|[3]Knasmüller S, et al. Toxic effects of griseofulvin: disease models, mechanisms, and risk assessment[J]. Critical reviews in toxicology, 1997, 27 (5) : 495-537.|[4]BEDFORD C, et al. Studies on the biological disposition of griseofulvin, an oral antifungal agent[J]. AMA Archives of Dermatology, 1960, 81 (5) : 735-745.|[5]Aldinger E E. Cardiovascular effects of griseofulvin[J]. Circulation Research, 1968, 22 (5) : 589-593.|[6]Ho Y S, et al. Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells[J]. International journal of cancer, 2001, 91 (3) : 393-401.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Microbial Metabolite

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