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Desmethoxyyangonin (Standard)

CAT: 0804-HY-N0918RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N0918RSize:1 Each
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Description
Desmethoxyyangonin (Standard) is one of the six major kavalactones found in the Piper methysticum (kava) plant. Desmethoxyyangonin (Standard) is a selective inhibitor of monoamine oxidase-B (MAO-B) (IC50: 0.123 µM) . Desmethoxyyangonin (Standard) exerts anti-inflammatory effects by inhibiting Jak2/STAT3 and IKK signaling pathways. Desmethoxyyangonin (Standard) induces CYP3A23 expression and leads to skeletal muscle relaxation[1][2][3][4].
CAS Number
15345-89-8
Product Name Alternative
Demethoxyyangonin (Standard) ; 5,6-Dehydrokavain (Standard)
UNSPSC
12352005
Target
Cytochrome P450; IKK; JAK; Monoamine Oxidase; NO Synthase; Reference Standards; STAT
Type
Reference Standards
Related Pathways
Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/desmethoxyyangonin-standard.html
Smiles
O=C1C=C(OC)C=C(/C=C/C2=CC=CC=C2)O1
Molecular Formula
C14H12O3
Molecular Weight
228.24
References & Citations
[1]Chaurasiya ND, et al. Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B. Evid Based Complement Alternat Med. 2017;2017:4018724.|[2]Chou TW, et al. A plant kavalactone desmethoxyyangonin prevents inflammation and fulminant hepatitis in mice. PLoS One. 2013 Oct 15;8 (10) :e77626.|[3]Baum SS, et al. Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats. Prog Neuropsychopharmacol Biol Psychiatry. 1998 Oct;22 (7) :1105-20.|[4]Ma Y, et al. Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23. Drug Metab Dispos. 2004 Nov;32 (11) :1317-24.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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