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Desmethoxyyangonin

CAT: 0804-HY-N0918-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0918-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Desmethoxyyangonin is one of the six major kavalactones found in the Piper methysticum (kava) plant. Desmethoxyyangonin is a selective inhibitor of monoamine oxidase-B (MAO-B) (IC50: 0.123 µM) . Desmethoxyyangonin exerts anti-inflammatory effects by inhibiting Jak2/STAT3 and IKK signaling pathways. Desmethoxyyangonin induces CYP3A23 expression and leads to skeletal muscle relaxation[1][2][3][4].
CAS Number
15345-89-8
Product Name Alternative
Demethoxyyangonin; 5,6-Dehydrokavain
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cytochrome P450; IKK; JAK; Monoamine Oxidase; NO Synthase; STAT
Type
Natural Products
Related Pathways
Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Desmethoxyyangonin.html
Purity
99.46
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C=C(OC)C=C(/C=C/C2=CC=CC=C2)O1
Molecular Formula
C14H12O3
Molecular Weight
228.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Chaurasiya ND, et al. Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B. Evid Based Complement Alternat Med. 2017;2017:4018724.|[2]Chou TW, et al. A plant kavalactone desmethoxyyangonin prevents inflammation and fulminant hepatitis in mice. PLoS One. 2013 Oct 15;8 (10) :e77626.|[3]Baum SS, et al. Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats. Prog Neuropsychopharmacol Biol Psychiatry. 1998 Oct;22 (7) :1105-20.|[4]Ma Y, et al. Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23. Drug Metab Dispos. 2004 Nov;32 (11) :1317-24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
INOS; JAK2; MAO-A; MAO-B; STAT3

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