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Dinutuximab

CAT: 0804-HY-P9933-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P9933-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dinutuximab (APN-311) is a chimeric human-mouse anti-GD2 monoclonal antibody. Dinutuximab can bind to GD2 on the cell surface, triggering antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity, and promoting tumor regression. Dinutuximab can inhibit the growth, invasion, and migration and induce apoptosis of tumor cells. Dinutuximab can be used in the research of tumors such as neuroblastoma and breast cancer[1][2][3].
CAS Number
1363687-32-4
Product Name Alternative
APN-311; Ch14.18; MAb-14.18
UNSPSC
12352203
Target
Apoptosis; mTOR; PERK
Type
Inhibitory Antibodies
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dinutuximab.html
Purity
99.0
Solubility
10 mM in DMSO|H2O
Smiles
[Dinutuximab]
Molecular Weight
(145.012 kDa)
References & Citations
[1]Ploessl C, et al. Dinutuximab: An Anti-GD2 Monoclonal Antibody for High-Risk Neuroblastoma. Ann Pharmacother. 2016 May;50 (5) :416-22.|[2]Barry WE, et al. Activated Natural Killer Cells in Combination with Anti-GD2 Antibody Dinutuximab Improve Survival of Mice after Surgical Resection of Primary Neuroblastoma. Clin Cancer Res. 2019 Jan 1;25 (1) :325-333.|[3]Ly S, et al. Anti-GD2 antibody dinutuximab inhibits triple-negative breast tumor growth by targeting GD2+ breast cancer stem-like cells. J Immunother Cancer. 2021 Mar;9 (3) :e001197.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Launched

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