Emodin

Emodin

• CAS Number: 518-82-1
• UNSPSC Description: Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction[1]. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice[3].
• Target Antigen: 11β-HSD; Autophagy; Casein Kinase; SARS-CoV
• Type: Natural Products
• Related Pathways: Anti-infection;Autophagy;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/Emodin.html
• Solubility: Acetone : 10.87 mg/mL (ultrasonic)|DMSO : 5.41 mg/mL (ultrasonic)|Ethanol : < 1 mg/mL (ultrasonic)
• Smiles: O=C1C2=C(C=C(C)C=C2O)C(C3=CC(O)=CC(O)=C31)=O
• Molecular Weight: 270.24
• References & Citations: [1]Tin-Yun Ho, et al. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction. Antiviral Res. 2007 May;74(2):92-101.|[2]Ying Feng, et al. Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice. Br J Pharmacol. 2010 Sep;161(1):113-26.|[3]Stefania Sarno, et al. Toward the rational design of protein kinase casein kinase-2 inhibitors. Pharmacol Ther. Feb-Mar 2002;93(2-3):159-68.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported