Emodin

• Description :

  Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction[1]. Emodin inhibits casein kinase-2 (CK2) . Anti-inflammatory and anticancer effects[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice[3].

• Product Name Alternative :

  Frangula emodin

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  11β-HSD; Autophagy; Casein Kinase; SARS-CoV

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Emodin.html

• Purity :

  99.39

• Solubility :

  Acetone : 10.87 mg/mL (ultrasonic) |DMSO : 5.41 mg/mL (ultrasonic) |Ethanol : < 1 mg/mL (ultrasonic)

• Smiles :

  O=C1C2=C(C=C(C)C=C2O)C(C3=CC(O)=CC(O)=C31)=O

• Molecular Formula :

  C15H10O5

• Molecular Weight :

  270.24

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Tin-Yun Ho, et al. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction. Antiviral Res. 2007 May;74 (2) :92-101.|[2]Ying Feng, et al. Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice. Br J Pharmacol. 2010 Sep;161 (1) :113-26.|[3]Stefania Sarno, et al. Toward the rational design of protein kinase casein kinase-2 inhibitors. Pharmacol Ther. Feb-Mar 2002;93 (2-3) :159-68.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  CK2

• CAS Number :

  [518-82-1]