Emodin

CAT: 0804-HY-14393-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-14393-01Size:50 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction[1]. Emodin inhibits casein kinase-2 (CK2) . Anti-inflammatory and anticancer effects[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice[3].
CAS Number
[518-82-1]
Product Name Alternative
Frangula emodin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
11β-HSD; Autophagy; Casein Kinase; SARS-CoV
Type
Natural Products
Related Pathways
Anti-infection; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Emodin.html
Purity
99.39
Solubility
Acetone : 10.87 mg/mL (ultrasonic) |DMSO : 5.41 mg/mL (ultrasonic) |Ethanol : < 1 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C=C(C)C=C2O)C(C3=CC(O)=CC(O)=C31)=O
Molecular Formula
C15H10O5
Molecular Weight
270.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Tin-Yun Ho, et al. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction. Antiviral Res. 2007 May;74 (2) :92-101.|[2]Ying Feng, et al. Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice. Br J Pharmacol. 2010 Sep;161 (1) :113-26.|[3]Stefania Sarno, et al. Toward the rational design of protein kinase casein kinase-2 inhibitors. Pharmacol Ther. Feb-Mar 2002;93 (2-3) :159-68.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CK2

Related Products

CatalogName
HY-134000Emodic acid

Alternative Products

CatalogName
TRC-E523000-100MGEmodin

Popular Products