Emodin

• UNSPSC Description:

  Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction[1]. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice[3].

• Target Antigen:

  11β-HSD; Autophagy; Casein Kinase; SARS-CoV

• Type:

  Natural Products

• Related Pathways:

  Anti-infection;Autophagy;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Emodin.html

• Solubility:

  Acetone : 10.87 mg/mL (ultrasonic)|DMSO : 5.41 mg/mL (ultrasonic)|Ethanol : < 1 mg/mL (ultrasonic)

• Smiles:

  O=C1C2=C(C=C(C)C=C2O)C(C3=CC(O)=CC(O)=C31)=O

• Molecular Weight:

  270.24

• References & Citations:

  [1]Tin-Yun Ho, et al. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction. Antiviral Res. 2007 May;74(2):92-101.|[2]Ying Feng, et al. Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice. Br J Pharmacol. 2010 Sep;161(1):113-26.|[3]Stefania Sarno, et al. Toward the rational design of protein kinase casein kinase-2 inhibitors. Pharmacol Ther. Feb-Mar 2002;93(2-3):159-68.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  518-82-1