Eliglustat-d15

Eliglustat-d15

• CAS Number: 1628700-80-0
• UNSPSC Description: Eliglustat-d15 (Genz 99067-d15) is deuterium labeled Eliglustat. Eliglustat is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC50 of 24 nM[1].
• Target Antigen: Isotope-Labeled Compounds; Others
• Type: Isotope-Labeled Compounds
• Related Pathways: Others
• Field of Research: Metabolic Disease;Cancer
• Smiles: [2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C(N[C@H](CN1CCCC1)[C@@H](C2=CC=C(OCCO3)C3=C2)O)=O
• Molecular Weight: 419.64
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]McEachern KA, et al. A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy ofGaucher disease. Mol Genet Metab. 2007 Jul;91(3):259-68.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported