Brophenexin

• UNSPSC Description:

  Brophenexin (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin shows neuroprotective activity. Brophenexin prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1].

• Target Antigen:

  ERK; iGluR; TRP Channel

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway;Membrane Transporter/Ion Channel;Neuronal Signaling;Stem Cell/Wnt

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/nmdar-trpm4-in-2.html

• Smiles:

  NCCN(CC1=CC=CC(Br)=C1)CC.[H]Cl.[H]Cl

• Molecular Weight:

  330.09

• References & Citations:

  [1]Yan J, et al. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science. 2020 Oct 9;370(6513):eaay3302.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  2243506-33-2