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Cernuumolide J

CAT: 0804-HY-N13294Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N13294Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cernuumolide J (TMJ-105) is an JAK2/STAT3 inhibitor. Cernuumolide J induces G2/M phase arrest and apoptosis in HEL leukemia cells by downregulating the phosphorylation of JAK2, STAT3, and Erk, and activating the phosphorylation of JNK and p38 MAPK. Cernuumolide J inhibits HEL leukemia cell growth in a time- and concentration-dependent manner, with an IC50 value of 1.79 μM. Cernuumolide J can be used for research in the field of anti-cancer therapy[1].
CAS Number
2019163-02-9
Product Name Alternative
TMJ-105
UNSPSC
12352005
Target
Apoptosis; ERK; JAK; JNK; p38 MAPK; STAT
Type
Natural Products
Related Pathways
Apoptosis; Epigenetics; JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cernuumolide-j.html
Smiles
CC(C)C(O[C@@H]1[C@]2([H])[C@@](C(C(O2)=O)=C)([H])[C@@H](C([C@@H](CCC[C@@]1(O)C)C)=O)OC(/C(C)=C\C)=O)=O
Molecular Formula
C24H34O8
Molecular Weight
450.52
References & Citations
[1]Wei X, et al. TMJ-105, an extract of Carpesium cernuum, induced G2/M phase arrest and apoptosis via the JAK2/STAT3 axis and MAPKs signaling pathway in leukemia HEL cells. Heliyon. 2024 Jul 5;10 (14) :e34115.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
JNK3; STAT3

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