Rabbit anti Human SPT16 (Intermediate Domain)

Rabbit anti Human SPT16 (Intermediate Domain)

• Background: SPT16 and SSRP1 are found in all eurkaryotic cells and exists as part of an essential heterodimer complex. Together, SPT16 and SSRP1 are a highly abundant nuclear complex that in mammals has been called FACT, or Facilitates Chromatin Transcription. FACT enhances the processivity of RNA polymerase II through nucleosomes. Evidence also points to a role for FACT in replication, possibly by enhancing DNA polymerase through nucleosomes as well.
• Synonyms: SSRP1
• CAS Number: 9007-83-4
• UniProt: Q9Y5B9
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Isotype: IgG
• Conjugation: Unconjugated
• Type: Polyclonal Antibody
• Applications: WB, IP
• Field of Research: Signal Transduction
• Purification Method: Ammonium Sulfate Precipitation
• Assay Principle: Antibody can be used for Western blotting (5-10 µg/mL) and immunoprecipitation. Optimal concentration should be evaluated by serial dilutions.
• Stability: See expiration date on vial
• Concentration: See vial for Concentration
• Form: Provided as solution in phosphate buffered saline with 0,08% sodium azide
• Precautions: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
• References & Citations: 1. Keller, D.M., et al. 'A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSPT16 and SSRP1.' Mol. Cell Biol. 2001, 7, 283-292
• Shipping Conditions: Ambient Temperature, freeze upon arrival
• Storage Conditions: Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
• Functional Analysis: WB