Begacestat

• Description:

  Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC50Aβ40=15 nM) for the treatment of Alzheimer's disease[1].

• Product Name Alternative:

  GSI-953

• UNSPSC:

  12352005

• Hazard Statement:

  H315-H319-H335

• Target:

  γ-secretase

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling; Stem Cell/Wnt

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Begacestat.html

• Concentration:

  10mM

• Purity:

  99.29

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  FC(F)(F)C([C@H](NS(=O)(C1=CC=C(Cl)S1)=O)CO)C(F)(F)F

• Molecular Formula:

  C9H8ClF6NO3S2

• Molecular Weight:

  391.74

• Precautions:

  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

• References & Citations:

  [1]Mayer SC, et al. Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease. J Med Chem. 2008 Dec 11;51 (23) :7348-51.|[2]Martone RL, et al. Begacestat (GSI-953) : a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. J Pharmacol Exp Ther. 2009 Nov;331 (2) :598-608.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  769169-27-9